Andrews, Shan V.
Sheppard, Brooke
Windham, Gayle C.
Schieve, Laura A.
Schendel, Diana E.
Croen, Lisa A.
Chopra, Pankaj
Alisch, Reid S.
Newschaffer, Craig J.
Warren, Stephen T.
Feinberg, Andrew P.
Fallin, M. Daniele
Ladd-Acosta, Christine http://orcid.org/0000-0002-7697-3998
Funding for this research was provided by:
National Institute of Environmental Health Sciences (R01ES019001, R01ES017646)
Burroughs Wellcome Fund (MD-GEM)
National Institutes of Health (MH089606)
Simons Foundation
Centers for Disease Control and Prevention (Cooperative Agreements under RFAs: 01086, 02199, DD11-002, DD06-003, DD04-001, and DD09-002)
Article History
Received: 8 March 2018
Accepted: 21 June 2018
First Online: 28 June 2018
Ethics approval and consent to participate
: This study was approved by the institutional review boards at each SEED site: SEED 1 recruitment was approved by the IRBs of each recruitment site: Institutional Review Board (IRB)-C, CDC Human Research Protection Office; Kaiser Foundation Research Institute (KFRI) Kaiser Permanente Northern California IRB, Colorado Multiple IRB, Emory University IRB, Georgia Department of Public Health IRB, Maryland Department of Health and Mental Hygiene IRB, Johns Hopkins Bloomberg School of Public Health Review Board, University of North Carolina IRB and Office of Human Research Ethics, IRB of The Children’s Hospital of Philadelphia, and IRB of the University of Pennsylvania. All enrolled families provided written consent for participation. This methylation substudy was approved as an amendment of the Johns Hopkins Institutional Review Board (IRB) approval. For participants from the Simons simplex collection, parents consented and children assented as required by each local institutional review board, which included a coalition of clinics located at Michigan, Yale, Emory, Columbia, Vanderbilt, McGill Washington, and Harvard Universities (Children’s Hospital of Boston), and at the Universities of Washington, Illinois (Chicago), Missouri, UCLA, and the Baylor College of Medicine. To protect the privacy of participants, Global Unique Identifiers (GUIDs) were constructed from personal information using an algorithm devised in collaboration with scientists at the NIH [CitationRef removed]. Each clinic retained personal identifiers on site and transmitted de-identified GUIDs to a central database, as described previously [CitationRef removed].
: Not applicable.
: The authors declare that they have no competing interests.
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