Salameh, Tarik J.
Roth, Katharine
Schultz, Lisa
Ma, Zhexi
Bonavia, Anthony S.
Broach, James R.
Hu, Bin
Howrylak, Judie A.
Funding for this research was provided by:
Eberly Medical Research Endowment Innovation Fund
National Center for Advancing Translational Sciences (UL1 TR000127)
Article History
Received: 24 May 2023
Accepted: 10 August 2023
First Online: 19 December 2023
Declarations
:
: All research was approved by an institutional review board. Authors report no conflicts of interest.
: The Institutional Review Board (IRB) at Penn State, Milton S. Hershey Medical Center approved this study (IRB reference: PRAMS041724EP).
: Prior studies of the gut microbiome in critically ill patients have indicated that specific taxa may be associated with increased mortality. In the current analysis, we extend these earlier findings by identifying a gut microbiome biomarker associated with increased mortality, and demonstrating how this biomarker may be used to enhance predictive models using clinical data alone.