Funding for this research was provided by:
National Natural Science Foundation of China (81571311, 81571331, 81725005)
National Basic Research Program of China (973 Program) (2016YFC0904300, 2016YFC1306900)
National High Tech Development Plan (2015AA020513)
Liaoning Science and Technology Project (2015225018)
Text and Data Mining valid from 2019-04-05
Received: 10 July 2018
Accepted: 24 March 2019
First Online: 5 April 2019
Ethics approval and consent to participate
: The study was approved by the Medical Science Research Ethics Committee of the First Affiliated Hospital of China Medical University (approval reference number25–1). All participants gave written informed consent before taking part in this study. Patients signed informed consent with the consent of their guardian, and all minor participants and their parents signed informed consent.
: Authors have obtained consent to publish from the participants to report patient data.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.