Funding for this research was provided by:
Cancer Research Wales (506719)
Wellcome Trust (504182)
Cancer Research UK (C16731/A21200)
Received: 10 December 2018
Accepted: 28 May 2019
First Online: 20 June 2019
Ethics approval and consent to participate
: This study was performed in accordance with the Declaration of Helsinki and human experimentation ethically approved by the Wales Research Ethics Committee (REC reference 15/WA/0292). The committee is constituted in accordance with the Governance arrangements for research ethics and complies fully with standard operating procedures for research committees in the UK. All subjects were over the age of 18 and gave written informed consent to take part in this study. Animal experimentation was ethically approved by the UK Home Office, performed under UK Home Office regulations and carried out by individuals holding a UK personal licence. Experimental protocol and handling was conducted in accordance with the UK Animals (Scientific Procedures) Act 1986 and The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) guidelines. An animal research: reporting of in-vivo experiments (ARRIVE) guidelines checklist for working with animals can be found in Additional file InternalRef removed.
: Not Applicable
: The authors declare that they have no competing interests.